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Diet induced obesity in rats pdf file – High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice

Diet-induced obese mice develop exhibit similar levels of weight gain may show different responses to peripheral, but not central, resistance to leptin. Oxford University Press is a department of the University of Oxford.

Thus, MPO is considered another marker of oxidative stress and inflammation. Blood samples were obtained from a tail tip cut before 0 min and at the following time points after glucose injection: 15, 30, 60, 90, and min. Interestingly, brown adipose tissue was hypertrophied in GK rats Fig 2G. Hruby, A. Food Sci. After 3 months of dietary exposure, HFD-exposed mice showed some deficits in sensorimotor integration.

  • Effect of fermented milk yogurt containing Lactobacillus acidophilus L1 on serum cholesterol in hypercholesterolemic humans. The physiological data collected in this study are consistent with our previous research

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  • The use of total protein stains as loading controls: an alternative to high abundance single-protein controls insemi-quantitative immunoblotting. The HFD group showed significant changes in motor activity, sensorimotor integration, and anxiety-like behavior as described below.

  • HF diet feeding in rats decreased the number of goblet cells, and this change was reversed by yogurt supplementation Fig.

ORIGINAL RESEARCH article

Rats pdf upper panel magnification is X10 and other panels magnification are X Elevated SFA and decreased SCD1 file in liver results diet induced hepatocellular apoptosis, steatohepatitis obesity fibrosis [ 75 ]. In these animals, liver and muscle responded well to insulin stimulus, even though liver was found to have a great fat accumulation. The results from the present investigation are also consistent with the findings from previous studies and showed a decrease in plasma cholesterol and triglyceride levels.

  • Mi, Y.

  • Consult with one of our scientists on ln formula, Diet for rapid weight loss for heart patients Mix S 10 0 10 0 determine the dosage required and the diet will be DiCalcium Phosphate 13 0 13 0 produced and shipped in 5 to 7 business days. The two groups used for primary comparisons were those that ate the HF or LF diet ad libitum, and they were included in every experiment.

  • The authors would like to declare that there is no conflict of interests regarding the publication of this paper.

RobertsS. WoodsStephen C. By carefully Casein, 80 Mesh designing the diet formula to fit your protocol, you have L-Cystine 3 12 3 12 complete control over small or large changes in diet composition. TremblayA.

Pdf file though HFD fed animals did not present an established insulin resistance diet induced obesity soleus fiet muscle, WAT insulin resistance was punctually rats. Dopamine DA is an important neurotransmitter regulating the food eating reward circuit, motor activity, and emotion 3 — 5. The choice of an experimental model is crucial to draw reliable conclusions and understand the correct pathophysiology of the disease, given the correct scenario. Animals received the specific diets for eight weeks [ 3233 ].

Introduction

Science Washington, D. LeanM. Stephen C. It was included to provide a link to the numerous reports that used nonpurified diets as the only control for an HF diet.

  • Fish oil supplementation for two generations increases insulin sensitivity in rats. Recently, genes involved in multiple pathways that may be associated with T2DM phenotype were observed in GK rats.

  • Dietary and environmental correlates of obesity in a population study in China. Cederroth C.

  • J Atheroscler Thromb.

  • Thus, rats consuming the HF diet gained increased body fat relative to rats eating either of two quite different LF diets.

  • Organ weights, especially the wet weights of the liver and fat, are important parameters for obtaining an understanding of diet-induced obesity.

  • Herein, two different models of rats were used to understand their differences and reliability as experimental models to obdsity the pathophysiology of T2DM, in two different approaches: the genetic GK rats and the environmental HFD-induced obese rats influences. A high fat diet HFD has been shown to increase the risk of neurodegenerative disorders such as Alzheimer's and Parkinson's disease in humans 12.

The stride length test was conducted separately for the front paw and rear paw. Figure 7. Relationship between obesity, alzheimer's disease, and parkinson's disease: an astrocentric view. M of the bands and n represents the number of animals used in each group.

Diet induced size table. Timmers, S. File dosages were carried out in the obesity by enzymatic-colorimetric method. However, the NO levels in the plasma and liver were not affected rats pdf control rats received the yogurt supplementation Fig. Contrary to the HFD fed rats, GK rats have lower fat accumulation in the white adipose tissue depots. Male Sprague-Dawley rats fed a high fat and sucrose diet performed worse in removing the adhesive tape compared to the control group The physiological data collected in this study are consistent with our previous research

Also, a vs b is significantly different. These results were also observed in rats. Sharma S, Fulton S.

Periodic acid Schiff PAS staining of the intestine revealed a substantial number of mucus-producing goblet cells both in crypts and villi of the diet induced obesity in rats pdf file rats Fig. The home cage nesting materials were placed in the obesityy goal box to attract the mouse to walk toward the finish point. Two microliters of derivatized lipid extract were injected and the fatty acid methyl ester peaks identified by comparison of retention times of fatty acid methyl ester standards and the chromatograms viewed in the Ce 1 h methods [ 39 ]. Genetics may be a key factor in the development of T2DM in societies where obesity is not a recurrent public health problem.

Search Menu. In all likelihood, the hyperinsulinemia in the Obexity rats was a result of insulin resistance, a common feature of human obesity and one that is central to the development of diabetes and cardiovascular disease. PopkinB. Animal rodent DR models are therefore useful tools for studying obesity as they will readily gain weight when fed high-fat diets 1, 2. Rat models including Obes Res ,

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  • Effect of yogurt supplementation on liver inflammation in HF diet fed rats. HFD induced obesity in Wistar rats.

  • Computer controlled electronics record food and water intake episodically by measuring the moment- to-moment, undisturbed intake behavior of the animals being studied. Some inbred strains are more susceptible to obesity when fed high-fat 2.

  • Xiao, J.

  • Citation Type. At a later date, each carcass was cut into four approximately equal coronal sections and weighed precisely.

  • Computer controlled electronics record food and water intake episodically by measuring the moment- to-moment, undisturbed intake behavior of the animals being studied.

  • A similar outcome was also observed in two separate experiments in which rats were restricted and lost weight.

Skip to search form Skip to main content You are currently offline. Diverse basal and stress-related phenotypes of Sprague Dawley rats from three since the animals gain weight until about 30 months of age These sections were dried to constant weight 4—5 d, typically using a high-capacity lyophilizer Labconco, Kansas City, MO. Lee and S. Plasma leptin concentrations for non food-restricted rats were Pediatrics 99 : E1 — E Lee and J.

Lee and S. However, these PHF rats had more carcass fat than LF rats, albeit the difference was significant only when both were compared with NP controls. The prevalence of obesity is increasing. This association of dietary fat with the incidence of obesity is exaggerated in some genetically isolated populations, such as the Pima Indians

Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet. The animals submitted to the hypercaloric diet presented a higher food intake in grams and in calories, resulting in increased weight gain and liposomatic index in comparison with the animals exposed to the control diet. Post-war course of the prevalence of extreme overweight among Danish young men. PHF diet. PrenticeA.

  • Only after 56 days of life, GK rats develop peripheral insulin resistance [ 19 ]. Body weight evaluation A and body weight gain B after 8 weeks of diet.

  • This duration was sufficient to remove all lipids from the carcass. Other strains are simply more resistant to obesity, such as the increases energy expenditure and decreases adiposity in mice.

  • Diet-induced obesity: dopamine transporter function, impulsivity and motivation. S12 Fig.

The oral glucose tolerance diet induced obesity in rats pdf file was performed in all groups at the beginning of the experiments, followed by a 12 hrs fasting. Diet induced obesity in rats pdf file length of strides indicate basal ganglia dysfunction 23 Design inducedd validation of a histological scoring system for nonalcoholic fatty liver disease. The results from the present investigation are also consistent with the findings from previous studies and showed a decrease in plasma cholesterol and triglyceride levels. Morpho-quantitative evaluations B considered cell density, hepatocyte and nuclear areas. Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats. The consumption of a high-fat and high-energy diet is considered a major cause of the development of these complications.

S Lavekar, A. Mice given the HFD diet exhibited significant decreases in motor activity and increases in anxiety-like behavior. Diet induced obesity in rats pdf file H. The HFD group showed significant changes in motor activity, sensorimotor integration, and anxiety-like behavior as described below. Consequently to the impairment in the capacity to secrete and produce insulin, the other characteristics follow up, such as hyperglycemia, increase in plasma fat and TG, liver inflammation, glucotoxicity and so on. Therefore, behavioral deficits in locomotion and anxiety are potential indicators of altered brain neuro-activity related to DA dysregulation. Chronic exposure to a high-fat diet HFD may predispose individuals to neuropathologies and behavioral deficits.

NP rats had a significantly larger decrease of glucose in response to the insulin than LF rats, and LF rats had a significantly greater decrease of glucose than HF rats. Diet induced obesity in rats pdf file response to pxf, blood glucose did not change in the HF rats Fig. The purposes of the experiments described in this report were to establish such a model and to determine whether the rats fed the HF diet share important characteristics with obese humans. BioDAQ E2 Episodic monitoring system measures the ad libitum food and water intake behavior of singly housed lab rats and mice at very high resolution in their home cage. Even within the same strain, different Environ Health Perspect ,

Using our paradigm, it will be possible to determine the mutability of defended body weight and other related questions that are of critical importance rats pdf designing rational weight reduction strategies. The diet induced obesity weight file of rats during indyced food deprivation and return to free access of food did not differ among groups Fig. Fortunately, there is a growing discussion with adult-onset obesity. The purposes of the experiments described in this report were to establish such a model and to determine whether the rats fed the HF diet share important characteristics with obese humans. Dozens of reports have addressed this question in human and animal models over the years, but there has been no consistency of outcomes or conclusions.

ReevesP. For the study of these pathologies, a number of animal models have been developed. PHF diet. AstrupA. Save to Library.

Covert manipulation of pdv dietary fat to carbohydrate ratio of isoenergetically dense diets: effect on food intake in feeding men ad libitum. Today, our high fat diets are the research standard for DIO mice worldwide. A second possible explanation as to why the HF rats became obese relates to the energy density of the diet.

Animal rodent DR models are therefore useful tools for ibesity obesity as they will readily gain weight when fed high-fat diets 1, 2. Download all slides. Obesity is a major health problem 1and despite considerable effort by scientists and health care professionals to understand and successfully treat obesity, its incidence continues to rise and the obesity-related health costs are staggering 2 — 7. Our scientists specialize in providing Ingredient gm kcal gm kcal custom purified OpenSource diets.

Rats fed a high-fat diet also developed glucose intolerance filr were unable to properly utilize glucose to establish homeostasis after a glucose challenge. These animals were obtained by repetition of selective breeding of glucose intolerant Wistar rats [ 15 ]. Mohammadi, A. Rats that consumed a high-fat diet exhibited increased plasma glucose levels and plasma lipid levels, including cholesterol and triglyceride levels.

MATERIALS AND METHODS

J Mol Endocrinol The diet induced obesity in rats pdf file groups used for primary comparisons were those that ate the HF or LF diet ad libitum, and they were included in every experiment. This association of dietary fat with the incidence of obesity is exaggerated in some genetically isolated populations, such as the Pima Indians Citing articles via Google Scholar.

View 1 excerpt, cites methods. Subject alert. View via Publisher. The weight of the carcass after being removed from the Soxlet was the fat-free lean tissue weight.

HFD has been shown to impair dopaminergic pathways in various rodent models. S9 Fig. HFD has been shown to disrupt dopaminergic pathways and generate diet induced obesity in rats pdf file behavioral deficits, but the duration of chronic HFD exposure needed to cause these effects is unclear. Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. A combination of various levels of dietary carbohydrates and fats from different sources, including nature, has been used in various NAFLD-related experimental studies 8 Full size image.

In imduced, omega-3 fatty acids have been including cookies, diet induced obesity in rats pdf file, cheese, and processed meats. In addition, they developed substantially more adipose tissue than control rats and acquired the insulin resistance and hyperleptinemia typically associated with obesity. Cite Cite Stephen C. These sections were dried to constant weight 4—5 d, typically using a high-capacity lyophilizer Labconco, Kansas City, MO. The Universal Definition of Heart Failure, risk prediction in cardiogenic shock, artificial intelligence in cardiac allograft rejection, and the genetics of dilated cardiomyopathy.

Woods, Randy Didt. Mean body weight was In the past decades, obesity and associated metabolic complications have reached epidemic proportions. Sign In. Carcass fat did not differ between the LF and NP females. However, the effects of diet-induced obesity on memory consolidation in female rats are poorly understood. This is important because both men and women, when they eat diets high in fat, have a tendency to become obese.

LF rats were fed significantly more energy per day than NP rats for the first week and afterwards had comparable energy intakes to NP rats. PriceR. Plasma leptin concentrations for non food-restricted rats were The potential antioxidant capacity and angiotensin I-converting enzyme inhibitory activity of Monascus-fermented soybean extracts: evaluation of Monascus-fermented soybean extracts as multifunctional food additives.

It was included to provide a link to the numerous reports that used nonpurified diets as the only control for an HF diet. Keywords: animal models; diet-induced obesity; high-fat diet; metabolic syndrome; microbiota; obesity. Open in new tab Download slide.

All other chemicals, solvents and reagents used in the present study were of diet for analytical dile. Nevertheless, it is important to consider that elevated basal hepatic loss for heart production as a consequence of decreased patients suppressive effect rapid weight hepatocytes, contribute to high glucose levels in plasma from GK rats [ 166970 ]. Collectively, these studies show that chronic intake of a HFD can disrupt dopaminergic function in rodents, but the initial time point when disturbances occur is not clear. However, since we only had measurements of dopaminergic molecules at the end of the dietary exposure, we can only suggest that the decreased motor activity, decreased sensorimotor integration, and increased anxiety-like behavior were associated with dopaminergic changes.

  • Mol Cell Endocrinol. High-fat diet feeding in rats was associated with a distorted microvilli structure and disoriented crypts compared to the control rats Fig.

  • Research Diets, Inc. However, the nutritive and non fish oil did not gain as much weight as those fed diets with more nutritive components of these foods are not well defined.

  • Counterintuitive effects of global warming-induced wind patterns on primary production in the Northern Humboldt current system. Alterations of the human gut microbiome in liver cirrhosis.

  • Nonetheless, we pdr that this difference is genuine and will be confirmed when further cohorts of rats are studied because rats in every cohort had group weights comparable to those whose carcasses were analyzed. As a consequence, although it is clear that consumption of an HF diet often leads to obesity, it cannot be unambiguously determined whether it is because of the increased total energy or a greater percentage of energy as fat with total energy held constant.

  • This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance. Thus, diet formulas may change Calories from Fat based on the nutritional composition.

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, diet induced future. A disruption in dopaminergic function has been positively obesity rats with behavioral deficits pdf file Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Clinical features of normal weight Japanese patients with type 2 diabetes who had formerly been obese. ImageJ software, which is freely available from the National Institutes of Health NIHwas used to measure the percentage of fibrosis in the liver and intestinal sections from each group.

Research Diets, Inc. Carcass fat did not differ between the LF and NP females. Thus, diet formulas may change Calories from Fat based on the nutritional composition. This dietary regimen has reproducible effects on body size and composition, and these are similar in male and female rats.

Diabetes At that point all three restricted groups were allowed free access to their respective diets. Research Feed. TremblayA. Launch Research Feed.

The paradigm also appears to be equally effective, at least on a diet induced level, in males and females. File daily energy intake of LF rats pdf was calculated every 3 d, and the yoked obesity were given that precise amount of energy each day, but as the HF diet. Because the emphasis in these experiments was on dietary fat, we equalized the amount of protein and all of the essential minerals and vitamins required for rats 30 per kJ for the HF and LF diets Table 1. Perhaps most important, the phenomenon is reliable and consistent from one experiment to the next. TuckerL.

At that point all three restricted groups were allowed free access to their respective diets. Composition of diet induced obesity in rats pdf file high-fat HF and low-fat LF diets used in expt 1—4 1. What is not clear is whether or how dietary fat per se is the predisposing factor, in particular because the incidence of obesity has tended to increase in the face of a slightly decreased mean fat intake in the United States 5 Share This Paper. The gut microbiota of SD rats was less abundant in Bacteroides and Prevotella but richer in Bifidobacterium and Lactobacillus comparatively to the gut microbiota of Wistar rats.

By comparing these rats with those in the LF and PHF groups, we were able to distinguish between the effects of obesity and dietary composition on these, and potentially other variables. This was in contrast to diet-induced obesity and resistance in Sprague-Dawley rats. To browse Academia.

  • Goto Kakizaki GK rat, a non-obese and spontaneous genetic T2DM experimental model, has been widely used to investigate the development of T2DM and its complications [ 9 — 14 ]. The effects of a high-fat sucrose diet on functional outcome following cortical contusion injury in the rat.

  • Dietary and environmental correlates of obesity in a population study in China.

  • The incidence of DM has risen vertiginously and, inas claimed by the World Health Organization WHOreached the hallmark of million individuals [ 2 ].

Three categories of behavior were tested in our study as indicators of initial signs of dopamine-related behavioral activities: motor activity, sensorimotor integration, and anxiety-like behavior. Obesity-related health complications are increasing in various societies worldwide. Fatty acid separation was achieved using a fused-silica column SP bis-cyano-propyl polysiloxane [ m length and 0. Download: PPT.

Nutriphenomics in rodent models By Michael Pellizzon. FlegalK. DOI: File comparing these rats with those in the LF and PHF groups, we rats pdf able to distinguish between the effects of obesity diet induced obesity dietary composition on doet, and potentially other variables. NP rats had a significantly larger decrease of glucose in response to the insulin than LF rats, and LF rats had a significantly greater decrease of glucose than HF rats. For some of the experiments the retroperitoneal and epididymal or ovarian fat pads were dissected and weighed before being returned to the carcass for subsequent analysis of total carcass fat. That is, these rats were fed the same proportion of dietary fat as the HF rats but had their energy intake yoked to that of the LF rats.

MeSH terms

Dietary and environmental correlates of obesity in a population study in China. AstrupA. However, a direct comparison between Wistar and Sprague-Dawley SD Rat as models of high-fat HF diet-induced obesity has not been adequately evaluated so far.

A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. PLoS One. Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats. At least 15 liver sections from three different animals in each group were analyzed and graded for hepatic lesions and fat deposition. C amount of dopamine transporter protein per gram of midbrain tissue.

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What tell us the GK rat model. S2 Fig. For the test trial, the time to cross and number of slips for the wide and narrow portions of the test were analyzed separately. Although the light-dark box test is commonly used to test anxiety-like behavior, both the open field and light-dark box tests still rely on locomotor exploratory behavior Metabolic assays 2.

  • AE- Control, showed normal distribution of goblet cells population in the crypt and villi region of intestine.

  • From a nutritional perspective, a human therefore provide consistency between batches. Chronic Disord.

  • Reduced glutathione GSH was obtained from J. As well described by the scientific literature, obesity is strongly associated to the development of metabolic complications leading to T2DM in the occident [ 48 ].

  • HF diet. Compared with rats fed the nonpurified diet, the HF rats had even more marked differences in these variables.

  • C amount of dopamine transporter protein per gram of midbrain tissue.

Oxidative stress rats pdf by the diet induced obesity of a high-fat file is evident in most experimental models and patients with clinical conditions 30 Even though obesity is a major cause of chronic inflammation associated to T2DM, patients that present a chronic inflammatory condition, such as periodontal disease, obstructive pulmonary disease, arthritis, myotonic dystrophy or chronic hepatitis C infection may also develop T2DM [ 51 ]. Dopamine DA is an important neurotransmitter regulating the food eating reward circuit, motor activity, and emotion 3 — 5. Browse Subject Areas?

Click here to sign up. The PHF diet induced obesity in rats pdf file were given their daily food allotment just before lights were turned off, and whereas most of them ate the majority of the food in one large meal early in the regimen, by the end of 10 wk their intake was spread over the day with food occasionally still remaining when new food was offered the next day. We developed a rat model of diet-induced obesity that will be a powerful tool for assessment of this issue. View Metrics.

Chronic Disord. Fortunately, there is a growing discussion with adult-onset obesity. Although it need fast diet lose weight clear that genetic factors contribute to the propensity of an individual to become obese, the striking increase in overweight that occurs as previously underdeveloped countries modernize and the continued growth in the numbers of obese individuals in developed countries indicate an important role for environmental factors as well. However, a direct comparison between Wistar and Sprague-Dawley SD Rat as models of high-fat HF diet-induced obesity has not been adequately evaluated so far.

A high fat diet HFD has been shown to increase the risk of neurodegenerative disorders diet for rapid weight loss for heart patients as Alzheimer's and Parkinson's disease in humans 12. Mohammadi, A. Other reports have also suggested beneficial effects of yogurt-containing probiotics on decreasing liver transferase activities, decreasing cholesterol levels and ameliorating NAFLD 19 Hyperglycemia per se is capable to promote inflammation in GK liver by altering the expression of genes that control pro and anti-inflammatory cytokines [ 70 ]. Three categories of behavioral tests for motor activity, sensorimotor integration, and anxiety-like behavior, were measured at the time points shown in Figure 1. In this study we investigate the molecular mechanisms of insulin resistance induced by two different models: GK rats genetic and HFD inducing obesity environmental—diet.

Three categories of behavior were tested in our study as indicators of initial signs of dopamine-related behavioral activities: motor activity, sensorimotor integration, and inruced behavior. Mice fed with a HFD show deficits in pre-attentive central information processing 9. Probiotics have many health-promoting effects, including the production of antimicrobial compounds, an improvement in immune functions and a decrease in the gut pH Ahsan or Md Ashraful Alam. J Nutr Biochem. Respir Physiol Neurobiol. Download: PPT.

As shown in the present study, the levels of the lipid peroxidation product malondialdehyde, nitric oxide and advanced protein oxidation ibduced were increased in high-fat diet fed rats. Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats. The beam traverse test analyzes fine motor coordination and balance in mice Ahsan or Md Ashraful Alam. Michael A.

Pef with neurodegenerative disorders often show deficits in sensorimotor integration. Effects of probiotics on biomarkers of oxidative stress diet for rapid weight loss for heart patients inflammatory factors in petrochemical workers: a randomized, double-blind, placebo-controlled trial. Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes. The consumption of a high-fat and high-energy diet is considered a major cause of the development of these complications.

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Diet induced obesity in rats pdf file, the NO levels in the plasma and liver were not affected in control rats received the yogurt supplementation Fig. Also, a vs b and c vs a or b are significantly different. The authors would like to declare that there is no conflict of interests regarding the publication of this paper. Lye, H. Bakhshimoghaddam, F. Correspondence to Gias U.

Save to Library. This model is therefore well suited for a systematic investigation of the role of dietary fat on body weight regulation and can be applied to many questions that are central to obesity research. Another strain, the FxBrown during diet-induced obesity. Some inbred strains are more susceptible to obesity when fed high-fat 2. FernstromG.

All rights reserved. DIO 0 Matched Formulas 4 7 10 13 16 19 22 25 28 When planning a diet-induced obesity study, the composition of the Age weeks high-fat diet deserves attention. Moore BJ.

Many high-fat diets used in laboratory animal In the early days of rodent diet-induced obesity research, some research contain more saturated fat such as lard, beef tallow, or scientists used what is known as the cafeteria diet. These sections were dried to constant weight 4—5 d, typically using a high-capacity lyophilizer Labconco, Kansas City, MO. Methods Citations. An important feature of the model is that it is consistent over numerous cohorts, enabling comparisons and generalizations over long time spans. The purposes of the experiments described in this report were to establish such a model and to determine whether the rats fed the HF diet share important characteristics with obese humans.

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B HF, showed collagen deposition and fibrosis as marked as red rats in diet induced obesity liver section. This process increases the bile acid synthesis from cholesterol through homeostasis and inhibits the saponification pdf file fatty acids to decrease fatty acid absorption from the gut After initial tissue removal basal conditionthe portal vein was accessed and 0. Moreover, periodic acid Schiff PAS staining was performed to identify the goblet cells in the intestine. Staining was performed to assess the intestinal histology, particularly the microvilli and crypts. In cases where behavior and biochemical data were analyzed at one time point, data were analyzed using an independent samples unpaired t -test. Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms.

The prevalence of obesity is increasing. AstrupA. Google Preview. Cederroth C.

Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Animal rodent DR models are therefore useful tools for studying obesity as they will readily gain weight when fed high-fat diets 1, 2. NP diet. MonteiroC. Although it is possible to independently vary energy density and the relative percentage of dietary fat, in our model the HF diet had an increase in both variables because we did not adjust the nonfat constituents of the diet to compensate for the increased energetic value of the additional fat.

Figures and Tables from this paper. Sucrose Chronic Disord. Many high-fat diets used in fils animal In the early days of rodent diet-induced obesity research, some research contain more saturated fat such as lard, beef tallow, or scientists used what is known as the cafeteria diet. Abstract The prevalence of obesity is increasing. A more comprehensive analysis in future experiments is needed to reveal if dietary fat content contributes more to body fat than energy content per se.

  • This study contributes to the field of nutrition and neuroscience because the identification of early signs of behavioral deficits may reflect initial dysregulation of dopaminergic or other neurochemical pathways, and this information is critical in understanding the progression of brain disorders induced by HFD.

  • Save to Library.

  • Weight gain in the HFD group was mainly by the accumulation of fat in the retroperitoneal and epididymal adipose tissue Fig 2D and 2E.

  • Effect of yogurt supplementation on intestinal cryptic and villi structure as well as fibrosis in intestinal basement layer in HF diet fed rats.

  • Based on the current investigation, yogurt supplementation also prevented the deposition of epididymal adipose tissue in high-fat diet-fed rats.

Bile salt hydrolase activity in probiotics. We expect that flle conclusion of this work help other researchers to choose their appropriate experimental model when aiming to study the causes and consequences of T2DM. Kaur, J. Marette, A. Front Neurosci. Get the most important science stories of the day, free in your inbox.

Woods, Randy J. Launch Research Feed. Citing articles via Google Scholar. Obesity is a major health problem 1 obesiyy, and despite considerable effort by scientists and health care professionals to understand and successfully treat obesity, its incidence continues to rise and the obesity-related health costs are staggering 2 — 7. Blood glucose concentrations after 5-h food restriction were not significantly different among groups 6. View 2 excerpts, references background.

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